Resumen

CONTRERAS E, ILSE et al. Lung volume determinations by whole plethysmography in cystic fibrosis patients: A preliminary report. Rev. chil. enferm. respir. [online]. 2008, vol.24, n.1, pp.20-26. ISSN 0717-7348.  http://dx.doi.org/10.4067/S0717-73482008000100004.

Introduction: Cystic fibrosis (CF) patients develop a progressive impairment of pulmonary function tests (PFT) by recurrent infection. Objective: To evaluate PFT in CF patients using spirometry, oxygen saturometry (Sa0₂) and whole plethysmography (WP) for determining possible mathematical relationships. Methods: FVC, FRC, RV, TLC, FEV₁, FEF25.75, obtained in 10 CF patients were compared with Zapletal's reference values and with the values obtained in 33 healthy-school children. Results: Mean age 13.6 years-old (range: 9-20). All CF patients had normal Sa0₂, FEV₁ was normal in five (four had FEV₁ between 65-80%), 4 had RV/TLC > 30%, 3 had increased FRC and RV/TLC, only one CF patient had WP normal. The average of TLC and RV were higher than reference values and control group (p < 0.05). We found an inverse relationship between FEV₁, FEF_25-75 and RV/TLC [r = -0.642 (p < 0.05) and r = -0.803 (p < 0.01); respectively]. Conclusion: This study suggests an increase of pulmonary volume in CF patients with not necessarily abnormal spirometry and an inverse mathematical relationship between FEV₁, FEF_25-75 and RV/TLC.

Palabras clave : Whole plethysmography; lung function; cystic fibrosis; children.

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