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Revista chilena de anatomía

versión impresa ISSN 0716-9868

Resumen

AGUILA, Marcia Barbosa  y  MANDARIM-DE-LACERDA, Carlos Alberto. CAN DIFFERENT LIPIDS DIETETICS AFFECT THE MYOCARDIAL STRUCTURE AND THE BLOOD PRESSURE INFLUENCING THE AGING PROCESS? EXPERIMENTAL STUDY IN RATS. Rev. chil. anat. [online]. 2001, vol.19, n.3, pp.317-324. ISSN 0716-9868.  http://dx.doi.org/10.4067/S0716-98682001000300014.

We studied sixty-seven male rats (Wistar strain) from birth until three different ages: 6-mo-old, 12-mo-old and 18-mo-old. The animals were separated according to the different experimental diets, i.e., soybean oil (S), canola oil (CA), lard and egg yolk (LE) and canola oil+lard and egg yolk (CA+LE). The systolic blood pressure (SBP) was verified weekly. The determination of the numerical density of the left ventricular myocyte nuclei (Nv[cm]) used the "optical disector" method. Considering all ages, the CA group rats had the Nv[cm] higher since 6-mo-old, whereas the other groups had almost the some values. The 18-mo-old, the CA group rats had a slight decrease of Nv[cm] but smaller than the other groups. The 18-mo-old rats had higher SBP and lower Nv[cm] than the younger ones, but in the CA group the SBP did not alter with the age and the reduction of the Nv[cm] was significantly lower than that of the other groups. Therefore, the variation in the SBP and the Nv[cm] was age-dependent but each experimental group had a different tendency. The elevation of the SBP and the reduction of the Nv[cm] was marked in the LE group, and intermediary in the other groups, suggesting that the density of the cardiac myocytes was influenced by the different dietetic lipids. In conclusion, the present study verified that the edible oil type in diet concerns the blood pressure and the numerical density of cardiac myocytes in rats during the aging process. The long-term canola oil diet produces beneficial structural myocardial changes and the attenuation of the blood pressure than other experimental diets, mainly the diet composing of lard and egg yolk

Palabras clave : Myocardium; Aging process; Stereology; Canola oil; Soybean oil.

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