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vol.19 issue3ULTRASTRUCTURE OF ENDOCRINE CELLS OF THE STOMACH (PROVENTRICULUS AND GIZZARD) OF THE RED-CAPPED CARDINAL (Paroaria g. gularis, LINNAEUS, 1766) author indexsubject indexarticles search
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Revista chilena de anatomía

Print version ISSN 0716-9868


VILELA, Antonella Sachsida Braga; COSTA, José Renán Vieira da; LOPES, Ruberval A.  and  SALA, Miguel A.. ACTION OF HYPERVITAMINOSIS A ON THE TOOTH GERM OF RAT FETUSES: HISTOLOGIC AND MORPHOMETRIC STUDY. Rev. chil. anat. [online]. 2001, vol.19, n.3, pp.231-238. ISSN 0716-9868.

The purpose of the present study was to characterize,  histologically and mrphometrically, the changes in the outer and inner epithelia of the dental organ of rat fetuses' molar tooth whose mothers had been injected with an excessive single doses of vitamin A during the teratogenic period (GD10). The histological analysis of the treated groups animals revealed that the outer and inner epithelia of the dental organ showed shorter cells with smaller nuclei. The morphometric study revealed that the epithelia of the dental organ showed smaller nuclei in the animals treated with vitamin A in excess, than the control animals, as well as those nuclei showed alteration of their shapes. The obtained results suggest that excessive vitamin A act on the odontogenesis and facial morphogenesis, leading to the birth of malformed fetuses

Keywords : Hypervitaminosis A; Fetus; Rat; Tooth germ; Morphometry.

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