SciELO - Scientific Electronic Library Online

vol.34 issue2Jaime Alvarez and the case against slow axoplasmic transport: some epistemological reflections author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Biological Research

Print version ISSN 0716-9760


ALVAREZ, JAIME. The autonomous axon: a model based on local synthesis of proteins. Biol. Res. [online]. 2001, vol.34, n.2, pp.103-109. ISSN 0716-9760.

In the current understanding of axons, axoplasmic synthesis of proteins is negated, and it is asserted that proteins are transported from perikarya to axons. This 'transport model' in which axons are fully dependent of perikarya is seriously flawed. The 'autonomous axon' proposed here negates in turn transport of proteins, and asserts (i) local synthesis of axoplasmic proteins, corner stone of this model, (ii) existence of internal programs in axon and terminals, (iii) external control of programs resulting in local regulation of phenotype of axons and terminals, hence they are autonomous from perikarya; (iv) participation of perikarya through the fast transport in setting up the axonal programs but not in their immediate regulation. The word merotrophism (meros meaning part) denotes post-transcriptional regulation of phenotype of restricted regions of a cell. We surmise that merotrophism is at the base of many plastic phenomena.

Keywords : plasticity; regeneration; Schwann cell; slow transport; sprouting; trophism; Wlds.

        · text in English


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License