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Revista chilena de infectología

versión impresa ISSN 0716-1018

Resumen

ROSANOVA, María T. et al. Experience with daptomycin in a tertiary pediatric hospital. Rev. chil. infectol. [online]. 2020, vol.37, n.1, pp.19-22. ISSN 0716-1018.  http://dx.doi.org/10.4067/S0716-10182020000100019.

Background:

Vancomycin has been considered the treatment of choice especially for methicillin-resistant Staphylococcus aureus (MRSA) infections; but its poor tissue penetration, renal toxicity, and requiring of dosages monitoring, raises the need for new treatment alternatives such as daptomycin.

Aims:

To analyze the safety and effectiveness of daptomycin in children.

Methods:

Children with microbiologically documented infections treated with daptomycin were retrospectively included.

Results:

The most frequent infections were endocarditis in 9 (32%), sepsis in 4 (14%), bacteremia in 7 (associated with catheter in 3) (25%), osteomyelitis in 3 (10%), peritonitis associated with dialysis in 3 (10%) and suppurative thrombophlebitis in 2 patients (p) (7%). Methicillin-resistant Staphylococcus aureus was the most common pathogen in 18 patients (64%). The indications for daptomycin were due to the failure of conventional treatment in 17 (61%), and the toxicity or intolerance to vancomycin in 11 patients (39%). The average duration of treatment was 19 days (95% ICR 7-42 days). Four patients (14%) completed outpatient treatment, 22 patients had a favorable response (79%). Adverse events were reported in 3 patients (2 creatinine-phosfo-kinase increase) and in one severe skin rash.

Conclusions:

Daptomycin demonstrated a favorable efficacy and safety in this pediatric population.

Palabras clave : Daptomycin; infections; children.

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