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Revista chilena de infectología

versión impresa ISSN 0716-1018

Resumen

MARTINEZ-METHOL, M. Soledad et al. Implementation of the reverse screening syphilis algorithm in a clinical laboratory. Rev. chil. infectol. [online]. 2019, vol.36, n.4, pp.525-530. ISSN 0716-1018.  http://dx.doi.org/10.4067/S0716-10182019000400525.

Background:

Syphilis remains a public health concern worldwide, the accuracy of diagnostic tests is critical for its successful control. Currently, there are two approaches to the diagnosis of syphilis using serological tests: the traditional algorithm and the reverse algorithm.

Aim:

The goal of this study was to analyse the advantages and disadvantages in the implementation of the syphilis reverse-screening algorithm in an outpatient clinical laboratory.

Methods:

An observational cross-sectional study was carried out analyzing 246 reactive sera from a total of 14700 requests for syphilis serology. Chemiluminescent assay ARCHITECT Syphilis TP, V.D.R.L. and FTA-Abs were performed.

Results:

Among 246 reactive sera by ARCHITECT Syphilis TP, 129 were reactive and 117 were non-reactive by V.D.R.L. the last mentioned resulted in 97 reactive and 20 non-reactive by FTA-Abs, suggesting false positives (0.13%). Two patients with primary infection were detected, that were not detected by V.D.R.L. and one pregnant woman with primary infection with a high value S/CO and V.D.R.L.:1 dils.

Conclusions:

Among the advantages of using a reverse algorithm were greater sensitivity in the detection of patients with primary syphilis; automation, complete traceability of the samples; objective interpretation and conclusive results.

Palabras clave : Syphilis; reverse algorithm for syphilis; treponemal chemiluminescence immunoassay.

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