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Revista chilena de infectología

versión impresa ISSN 0716-1018

Resumen

ESPINOZA, Ricardo; QUERA, Rodrigo; MEYER, Lital  y  RIVERA, Daniela. Fecal microbiota transplantation: first case report in Chile and review. Rev. chil. infectol. [online]. 2014, vol.31, n.4, pp.477-482. ISSN 0716-1018.  http://dx.doi.org/10.4067/S0716-10182014000400016.

Clostridium difficile (CD) infection is increasing in frequency and severity in in-hospital and outpatient clinical settings, with a recurrence that can reach 30% after first episode. The recurrences are usually treated with longer courses of metronidazole or vancomycin. Other treatments have been used, such as probiotics, fidaxomicin, rifaximin, immunoglobulins and monoclonal antibodies against toxins A and B. Fecal microbiota transplantation (FMT) has emerged as a promising strategy in this group of patients, with effectiveness greater than 90%. We present the first case reported in Chile of this therapeutic strategy in a patient with Crohn's disease and recurrent CD infection who presented after the fecal transplantation an Escherichia coli bacteremia, suggesting the need for caution in the use of this strategy. 10 months after the FMT the patient presented a new episode of E. coli bacteremia and two episodes of diarrhea due to CD infection, treated both of them with vancomycin with good clinical response.

Palabras clave : Fecal transplantation; bacteremia; Clostridium difficile; Crohn's disease; inflammatory bowel disease.

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