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Revista chilena de infectología

versión impresa ISSN 0716-1018

Resumen

RODRIGUEZ Z., NATALIE et al. Usefulness of G-CSF in pediatric high risk cancer patients with fever and neutropenia. Rev. chil. infectol. [online]. 2005, vol.22, n.3, pp.223-227. ISSN 0716-1018.  http://dx.doi.org/10.4067/S0716-10182005000300001.

Chemotherapy associated febrile neutropenia is an important cause of morbidity and mortality in pediatric patients with cancer. The use of granulocyte_colony stimulating factor (G-CSF) post chemotherapy decreases the risk of infectious complications but its efficacy during the febrile neutropenic episode remains controversial. Thirty five episodes of high-risk febrile neutropenia were randomized into two treatment arms, 18 received antibiotics and G-CSF (group A) and 17 received antibiotics only upon admission (group B). Both groups were comparable in terms of demographic and clinical characteristics. No significant differences between groups were found in duration of hospitalization (mean group A 7 vs group B 8 days), antibiotic treatment (mean 7 vs 8 days), fever (3 vs 2 days), nor of neutropenia (4 vs 3 days). One patient in group A died after RSV infection. Considering these results and a literature review, we propose that G-CSF should not be recommended in children during the course of their febrile neutropenic episode

Palabras clave : Pediatrics; Cancer; Febrile neutropenia episodes; Granulocyte colony stimulating factor.

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