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Revista chilena de infectología

versão impressa ISSN 0716-1018

Resumo

SALAZAR J, Aurora et al. EVALUATION OF DIAGNOSTIC METHODS FOR CONGENITAL SYPHILIS. Rev. chil. infectol. [online]. 2000, vol.17, n.4, pp.289-296. ISSN 0716-1018.  http://dx.doi.org/10.4067/S0716-10182000000400002.

Congenital syphilis is a relevant problem in our country. At the present, no routine method is available to verify the diagnostic. This multicenter prospective study recruited serum samples reactive for VDRL of sixty mothers with their respective infant (n = 120). In addition to the routinely used screening assay (RPR, VDRL) the following tests were performed: serological detection of specific antibodies to Treponema pallidum for IgM ( PathozymeÒ, CaptiaÒ IgM), for IgG (CaptiaÒ IgG) and for IgG/IgM ( MHA-TP; Pathozyme competitionÒ, ICE SyphilisÒ, DetermineÒ). A good agreement was observed between the immunoassays for IgG alone or IgG/IgM (90%) and for IgM alone or IgG/IgM (87.5%). Every mother who had syphilis in the moment of the study or had had syphilis before, and her newborn child, were positive for IgG. Only 64% of the mothers with adequate treatment during their pregnancy had a positive titer for IgM and all of their newborn were not reactive for IgM. The mothers whose treatment was inadequate had IgM titers positive in 82.3% and their children had IgM positive in 11.8%. No correlation was found between a positive maternal IgM titer and the risk of the infant to present the disease. The newborn IgM titer is a useful parameter for an early diagnosis but a negative result cannot discard this pathology.

Palavras-chave : Syphilis; Congenital; Diagnosis; Laboratory test.

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