SciELO - Scientific Electronic Library Online

 
vol.91 número6Caracterización de recién nacidos a término con deshidratación hipernatrémicaPrevalencia de Hipertensión Arterial en una unidad de cuidados intensivos neonatales índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Compartir


Revista chilena de pediatría

versión impresa ISSN 0370-4106

Resumen

DOMINGUEZ-MENENDEZ, Gonzalo et al. Seasonal variations in 25-hydroxy vitamin D3, parathormone and alkaline phosphatase in school-aged children. Rev. chil. pediatr. [online]. 2020, vol.91, n.6, pp.881-890.  Epub 05-Nov-2020. ISSN 0370-4106.  http://dx.doi.org/10.32641/rchped.vi91i6.2282.

Introduction:

The main role of Vitamin D is to regulate calcium metabolism, whose main source is vitamin D3 ob tained mostly from the action of ultraviolet (UV) light on the skin.

Objective:

To evaluate the seaso nal differences in the concentrations of 25-hydroxy-vitamin D3 (25OHVitD3), parathyroid hormone (PTH), alkaline phosphatase (ALP), and calcium in school-age children.

Subjects and Method:

The concentrations of 25OHVitD3, PTH, ALP, and calcium were measured in children from Santiago, Chile (latitude -33.4372), aged 5 to 8 years, without Vitamin D supplementation, in different seasons of the year. VitD status was defined as sufficient with concentrations of 25OHVitD3 >20 ng/mL (50 nmol/L), insufficient 12-20 ng/mL (30-50 nmol/L) and deficient <12 ng/mL (30 nmol/L) based on the recommendations of the expert group of the “Global Consensus for the Prevention and Mana gement of Nutritional Rickets”.

Results:

133 children participated (89 preterms under or equal to 32 weeks), 41 during summer, 28 in fall, 35 in winter, and 29 in spring. The difference of means between summer and winter was 9.6 ng/mL for 25OHVitD3 (p <0.0001), -11.1 pg/mL for PTH (p <0.0001), and -47.5 IU/mL for ALP (p= 0.01). There were no differences in calcium concentrations. In sum mer, 97.6% of the subjects were classified with sufficiency status (> 20 ng/mL), which decreased significantly in winter to 54.3% (p <0.0001).

Conclusions:

In winter, 25OHVitD3 concentrations decreased in approximately half of the children, which was associated with an increase in PTH and ALP, and normal calcium concentrations. According to our results, children may need VitD supple mentation during fall and winter.

Palabras clave : Parathyroid Hormone; 25OHVitD3; Alkaline Phosphatase; UV Index; Seasons.

        · resumen en Español     · texto en Español     · Español ( pdf )