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Revista chilena de pediatría

versão impressa ISSN 0370-4106


LACOURT, Patricia et al. Granulosa cell ovarian tumor: precocious puberty in infant less than 1 year of age. Case report. Rev. chil. pediatr. [online]. 2017, vol.88, n.6, pp.792-797. ISSN 0370-4106.


Juvenile granulosa cell tumors (JGCT) are very rare, especially in infants under the age of one. The most frequent presentation is with signs of precocious puberty.


Present an in fant with peripheral precocious puberty, diagnosis of JGCT and follow up.

Clinical case:

10-month-old female infant with thelarche, pubic hair and palpable abdominal mass accompanied with eleva ted levels of estradiol, very low gonadotrophins and images that show a very large ovarian mass. A sapingooforectomy was carried out with full regression of symptoms and signs and improvement of laboratory exams. The biopsy showed TCGJ so inhibin B (InB) was taken as tumoral marker after surgery. This hormone was high initially, but rapidly declined. Follow-up was based on InB, antimu-llerian Hormone (AMH) and estradiol as described in this type of tumors.


Juvenil gra nulosa cell tumors are very infrequent in pediatric age, but should be suspected in girl with peripheral precocious puberty. The majority of cases improve with surgery, but strict surveillance of tumoral markers is needed. The most specific markers are inhibin B and anti mullerian hormone (AMH), followed by estradiol levels.

Palavras-chave : Granulosa cell ovarian tumor; peripheral precocious puberty; inhibin B; anti mullerian hormone.

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