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Revista chilena de pediatría

versión impresa ISSN 0370-4106

Resumen

AVILES ESPINOZA, Carolina; BERMUDEZ MELERO, Carla; MARTINEZ AGUAYO, Alejandro  y  GARCIA BRUCE, Hernán. Adult height of children with idiopathic short stature treated with growth hormone therapy. Rev. chil. pediatr. [online]. 2016, vol.87, n.1, pp.37-42. ISSN 0370-4106.  http://dx.doi.org/10.1016/j.rchipe.2015.10.013.

Introduction: Idiopathic short stature (ISS) is defined as a height of < - 2 standard deviations (SD) from the mean for age. The use of Growth Hormone (GH) in ISS is controversial, and there are not results for adult height (AH) in Chilean patients with ISS treated with GH. The objective of the study is to compare AH in patients treated with GH with the height prediction at beginning of treatment. Patients and Method: AH was considered with bone age ≥ 17 in males and ≥15 in females. The height SD according to the NCHS curves at beginning and ending of treatment were used for the comparison. Height prediction (HP) was calculated by Bayley-Pinneau method. Results: AH was reached by 18/47 patients with ISS treated with GH. Initial height -2.1 ± 0.85 SD (133.1 ± 6.8 cm) and HP -1.94 ± 0.86 SD, and were treated since 11.6 ±1.2 years old. After one year of treatment their height was -1.64 ±0.69 SD, and AH was -1.28 + -0.62 SD (163.76 +-7.22 cm). Conclusion: It is suggested that treatment with GH for ISS is effective to increase AH. Although with wide individual variability, a mean increase of 0.67 ± 0.9 SD (+2.67 cm) was obtained in the AH. This is the first report on Adult Height in Chilean patients.

Palabras clave : Idiopathic short stature; Body height.; Growth disorders.; Treatment outcome Growth Hormone..

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