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Revista chilena de pediatría

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CRUZ O, MAGDALENA; DOREN V, ADRIANA; TAPIA I, JOSÉ LUIS  and  ABARZUA C, FERNANDO. Group B Streptococcus neonatal sepsis: up-to-date. Rev. chil. pediatr. [online]. 2008, vol.79, n.5, pp.462-470. ISSN 0370-4106.

Group B Streptococcus is one of the leading bacterias causing early onset neonatal sepsis. It constitutes an important factor of neonatal morbidity and mortality and high costs in health. Many strategies have been formulated to avoid vertical transmission from the colonized mother to the newborn, in an attempt to prevent infection of the infant. The most used nowadays is antibiotic prophylaxis given to the mother during labor, depending on the results of recto-vaginal culture taken during 35 to 37 weeks of gestation. This strategy has importantly diminished the prevalence of early onset neonatal sepsis by this agent, although there is still concern about the potential generation of antibiotic resistance and drug-induced adverse reactions in the mother. New techniques for prevention are being developed, such as vaccines against Streptococcus. In the newborn, infection caused by Streptococcus has a broad spectrum of clinical manifestations, like sepsis and meningitis which are the most frequent and lethal. Neurological sequelae are common among the survivors, so an early suspicion of disease must lead to a prompt antibiotic treatment.

Keywords : Sepsis; newborn; neonate; morbility; mortality.

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