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Revista chilena de pediatría

versión impresa ISSN 0370-4106

Resumen

KOFMAN, CARLOS; TEPER, ALEJANDRO; VIDAURRETA, SANTIAGO  y  KOHLER, MARÍA TERESA. Salbutamol bronchodilatatory response administered in pressurized aerosol through aerocameras with valves or not válvula spaciators. Rev. chil. pediatr. [online]. 2008, vol.79, n.4, pp.433-433. ISSN 0370-4106.  http://dx.doi.org/10.4067/S0370-41062008000400015.

Introduction: Inhalation therapy is the most frequent route for administration of asthma treatment. The utility of spacers added to metered dose inhalers (MDI) is well established. However, non-valved spacers have recently been proposed as equally effective as the valved holding chambers, and more cost-effective. Clinical efficacy of non-valved spacers is not well established yet. Objective: To compare the bronchodilator response to albuterol administered by MDI with a valved holding chamber vs. a non-valved spacer. Patients and methods: In a experimental, prospective, randomized, simple blind, parallel group study, 34 asthmatic children from 6 to 16 years oíd with mild or modérate bronchial obstruction (forcé expiratory volume in the first second, FEV¡ 50 to 79% of predicted) without recent treatment whit bronchodilating agents were randomly assigned to be treated with 100 mg of albuterol MDI (Ventolin ™, MDI) either through a valved (Aerochamber4™1) oranon-valved (Aeromed4™1) spacer. After 30 minutes, a bronchodilating response was determined through FEV, and FMF measurements. Results: 17 patients used the valved holding chamber (12 male, baseline FEV! 67 ± 10%) and 17 the non-valved spacer (13 male, baseline FEV! 67 ± 6%). Vanation of FEVi was 26 ± 14% and 16 ± 5% (p = 0,017) and vanation of forced médium flow (FMF) was 92 ± 48%o and 58 ± 29%> (p < 0.018) for the valved holding chamber and for the non-valved spacer, respectively (ANOVA test). Conclusión: Albuterol administered by MDI through valved spacer produced a greater bronchodilator response than through non-valved spacer in asthmatic children

Palabras clave : spacers; bronchodilator response; asthma.

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