SciELO - Scientific Electronic Library Online

vol.77 issue4Morbidity and mortality of newborns with birth weight less than 1 500 g: Experience from a local hospital part of the Vermont Oxford NetworkChronic pulmonary aspergillosis associated to multiple airway papillomatosis: Case-report and literature review author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Revista chilena de pediatría

Print version ISSN 0370-4106


EYZAGUIRRE C, Francisca et al. Type I diabetes mellitus in Chilean children under 5 years-old: Onset characteristics in contrast with other age groups. Rev. chil. pediatr. [online]. 2006, vol.77, n.4, pp.375-381. ISSN 0370-4106.

: During the last years, an increase in the incidence of DM1 in infants has been observed. Objective: to study the number of children younger than 5 years-old diagnosed with DM1 and compare clinical and laboratory features with older children at DM1 onset. Method: Study of the clinical and laboratory characteristics in subjects diagnosed with DM1 from 1998 to 2003 in Santiago. Patients were classified according to age in 3 groups: 0-4 (GI), 5-9 (GII) and 10-14 years-old (GIII). Results: 19,7% cases were younger than 5 years-old (GI n = 27), GII (43,8% n = 60) and GIII (36,5% n = 50). A shorter duration of symptoms was observed in GI (18,4 ± 23,7 vs 26,4 ± 27,4) (p < 0,0001) and HbA1c levels were lower in GII (10,1 ± 1,7 vs 11,8 ± 3,4%) (p < 0,0001) and in GIII (12,4 ± 2,6%) (p = 0,028). Glucose levels were similar among groups (p>0,05) and metabolic acidosis was more severe in GI (pH 7,14 ± 0,1 vs 7,19 ± 0,2 in GII and 7,26 ± 0,1 in GIII) (p < 0,0001). A concomitant infectious disease was observed in GI (33%), GII (20%) and GIII (28%) (p > 0,05). Conclusions: An important percentage of DM1 in children presents in subjects younger than 5 years-old. This group showed acute and severe clinical presentation with longer duration of symptoms, severe acidosis and lower HbA1c levels. It is necessary to evaluate carefully in order to suspect the diagnosis in this group

Keywords : diabetes mellitus type 1; onset; children; Chile.

        · abstract in Spanish     · text in Spanish


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License