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Revista chilena de pediatría

versión impresa ISSN 0370-4106


SANCHEZ D., Ignacio et al. Comparación entre dos métodos de determinación del test del sudor en el diagnóstico de la fibrosis quística. Rev. chil. pediatr. [online]. 1999, vol.70, n.4, pp.281-287. ISSN 0370-4106.

The diagnosis of CF has been traditionally determined using the quantative pilocarpine iontophoresis method. Recently there has been developed a new system of collection and analysis of sweat that is easy to perform and gives results comparable to the traditional method. Our object was to evaluate the Macroduct® collection system and the analysis using conductivity (C), comparing the results with the reference method of flame photometry (FP). 74 children refered to the laboratory were studied, 60 of which the diagnosis of CF was excluded (normal controls) with an age of 2,7 &plusmn; 3.2 years (X &plusmn; SD), and 14 with CF previously diagnosed with ages 6.1 &plusmn; 6.3 years. Sweat was obtained with the Macroduct® system, which consists of cutaneous stimulation using pilocarpine iontophoresis with direct collection of sweat into a plastic receiver using a flexible spiral capillary tube. Samples were analized for the concentrations of sodium (Na) and potassium (K) using C and FP and derived from the intensity of absorption of the specific wavelength for each ion. In the controls the combined Na + K using C was 28.2 &plusmn; 7.9 (range 19-55 mmol/l), and using PF 27.4 &plusmn; 10.1 (p = ns, r = 0,98, p < 0.001). In patients with CF using C the results were 113.4 &plusmn; 9.4 mmol/l (range 98-128 mmol/l), and with PF 116.3 &plusmn; 12.8 (range 92-139) (p = ns, r = 0,98, p < 0.001). Using the Macroduct® system there was no patient with CF using C with a result less than 98 mmol/l, or controls with a result more than 55 mmol/l. The results confirm that the Macroduct® system and analysis using C is a simple, rapid and reliable technique that could be of great use to improve the diagnosis of CF

Palabras clave : cystic fibrosis; sweat test; flame photometry.

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