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Revista médica de Chile

versión impresa ISSN 0034-9887


VALLADARES, Ximena et al. Clinical and epidemiological characteristics of the Philadelphia negative myeloproliferative neoplasms in Chile. Rev. méd. Chile [online]. 2021, vol.149, n.12, pp.1687-1693. ISSN 0034-9887.


Philadelphia-negative myeloproliferative neoplasms (Ph-MPN) are chronic hematological disorders characterized by the overproduction of one or more mature myeloid blood cell lineages. Classical Ph-MPN are polycythemia vera (PV), essential thrombocytopenia (ET) and primary myelofibrosis (PMF).


To assess the epidemiological, clinical and diagnostic characteristics of Ph-MPN in Chile.

Material and Methods:

Retrospective review of medical records of all patients referred as MPN from 2012 to 2017. Patients with (9;21) translocation were excluded.


Data of 462 cases with a median age of 69 years from 10 public hospitals was reviewed. ET was the most frequently Ph-MNP found. The incidence of Ph-MPN was 1.5 x 100.000 cases. The JAK2 V617F mutation study was performed in 96% of patients and only 30% had a bone marrow biopsy. Thrombotic events were observed in 29% of patients. Bleeding events were observed in 7%. Five-year overall survival was 87%.


ET is the most frequent Ph-MPN. The mean incidence was lower than reported in the literature, in part because of a sub diagnosis.

Palabras clave : Janus Kinase 2; Polycythemia Vera; Primary Myelofibrosis; Thrombocythemia; Essential.

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