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Revista médica de Chile

versão impressa ISSN 0034-9887


VERA, Constanza et al. Subacute encephalopathy associated with relapsing polychondritis. Report of one case. Rev. méd. Chile [online]. 2021, vol.149, n.7, pp.1085-1089. ISSN 0034-9887.

Relapsing polychondritis (RP) is a rare multisystemic autoimmune disorder characterized by the inflammation and destruction of cartilages, with preference for auricular, nasal and laryngotracheal cartilages. RP may also affect proteoglycan-rich structures, such as, blood vessels, eyes, kidneys, and heart. The central nervous system (CNS) is involved in less than 3% of patients. We report a 32-year-old female with RP associated with a progressive subacute encephalopathy characterized by behavioral disturbances, auditory and visual hallucinations. The EEG showed generalized slow activity and a mononuclear pleocytosis with increased protein was found in the cerebrospinal fluid. The brain magnetic resonance imaging showed multiple supra and infratentorial nodular inflammatory lesions. After initiating treatment with corticosteroids and cyclophosphamide, a significant improvement in chondritis and neurological status was observed.

Palavras-chave : Brain Diseases; Leukocytosis; Polychondritis, Relapsing.

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