SciELO - Scientific Electronic Library Online

vol.149 número1Nuevas perspectivas en el manejo de la hipertensiónInactividad física versus sedentarismo: análisis de la Encuesta Nacional de Salud de Chile 2016-2017 índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google


Revista médica de Chile

versión impresa ISSN 0034-9887


HUIDOBRO E., Juan Pablo; GUZMAN, Ana María  y  TAGLE, Rodrigo. Use of cystatin C to estimate glomerular filtration rate. Rev. méd. Chile [online]. 2021, vol.149, n.1, pp.98-102. ISSN 0034-9887.

Glomerular filtration rate (GFR) is routinely estimated using endogenous biomarkers due to the complexity of direct measurement methods. Cystatin C is a protease inhibitor produced in all nucleated cells. It is freely filtered and then catabolized by renal tubular cells. Therefore, plasma concentration of cystatin C depends primarily on GFR. Serum cystatin C is less affected by muscle mass, diet, race, gender and age than creatinine. In the general population, equations to estimate GFR based on cystatin C do not have a better performance than those based on creatinine. However, formulas that combine creatinine and cystatin C are more accurate and precise. Estimation of GFR based on cystatin C could be useful in populations in which creatinine value may be biased, such as people with extremely low or high muscle mass, cirrhosis and chronic cardiorenal syndrome. Due to its higher cost in comparison to creatinine, we recommend measuring cystatin C on these clinical situations and when a more accurate estimation of GFR is required.

Palabras clave : Cystatin C; Glomerular Filtration Rate; Kidney Function Tests.

        · texto en Español     · Español ( pdf )