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Revista médica de Chile

Print version ISSN 0034-9887


SEPULVEDA, Rodrigo A.; BARNAFI, Esteban; ROJAS, Vicente  and  JARA, Aquiles. Methemoglobinemia caused by dapsone. Report of one case. Rev. méd. Chile [online]. 2020, vol.148, n.12, pp.1838-1843. ISSN 0034-9887.

Methemoglobinemia is a rare condition with serious consequences if not diagnosed. We report the case of a 64-year-old woman with a history of allergy to sulfa drugs and a recent diagnosis of a small vessel vasculitis (ANCA-p) who started induction therapy with corticosteroids and rituximab. Due to the need for infectious prophylaxis, and considering her history, dapsone was administered instead of cotrimoxazole after ruling out glucose-6-phosphate dehydrogenase deficiency. During the admission to the hospital for her second dose of rituximab, and while being asymptomatic, she persistently presented a pulse oximetry ≪ 90% despite the administration of O2. Therefore, the infusion was postponed to study the patient. The arterial gasometric study by direct potentiometry revealed an O2 saturation of 98%, with a saturation gap > 5%. Considering the use of dapsone, a methemoglobinemia was suspected and confirmed by co-oximetry (methemoglobinemia 9%). Dapsone was suspended and one week later, her methemoglobinemia was absent.

Keywords : Blood Gas Analysis; Dapsone; Methemoglobinemia; Methylene Blue.

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