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Revista médica de Chile

Print version ISSN 0034-9887

Abstract

OLIVARES, Felipe et al. Clinical features of 47 patients infected with COVID-19 admitted to a Regional Reference Center. Rev. méd. Chile [online]. 2020, vol.148, n.11, pp.1577-1588. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872020001101577.

Background:

During the first pandemic wave, Covid-19 reached Latin America cities.

Aim:

To report clinical features and outcomes of a group of patients with Covid-19 admitted to a Chilean regional reference Center.

Material and Methods:

Cases were identified by a compatible clinical picture and a positive PCR or serological test. Clinical features of patients were retrieved from medical records.

Results:

Forty-seven adult patients (45 diagnosed by PCR, 2 by serology) were admitted between epidemiological weeks 13 to 33, corresponding to 4.4% of total regional cases. Hospitalization occurred at a median of 10 days after onset of symptoms. Fifty one percent of patients had 60 years or more. Hypertension, obesity and diabetes mellitus were present in 57, 45 and 32 % of cases, respectively. Nineteen percent of patients had no comorbid condition nor were elderly. Two cases were women in their second trimester of pregnancy. Positive IgM or IgM/IgG results obtained by rapid serological testing, had limited sensitivity during the first week (67%). Seventeen patients (36.2%) were transferred to an intensive care unit (ICU) due to respiratory failure. Chest imaging demonstrated a classical COVID-19 pattern in 87%. By univariate analysis, admission to ICU was significantly associated with tachypnea and higher CALL (comorbidity, age, lymphocyte count and lactate dehydrogenase) score. Four patients died (rendering a hospital mortality of 8.5%) and length of stay was ≥ 14 days in 46.8% of patients. By univariate analysis, mortality was associated with immunosuppression and ICU admission.

Conclusions:

In our regional Center, patients admitted with COVID-19 had usual risk factors and had a prolonged stay. Hospital mortality was associated with immunosuppression and ICU admission.

Keywords : COVID-19; Critical Care; Pneumonia; Real-Time Polymerase Chain Reaction; Serologic Tests.

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