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Revista médica de Chile

Print version ISSN 0034-9887


PENA, Camila et al. AL amyloidosis in the Chilean public health system: a pending debt. Multicenter study of the Chilean Monoclonal Gammopathies Cooperative Group. Rev. méd. Chile [online]. 2019, vol.147, n.10, pp.1239-1246. ISSN 0034-9887.


Immunoglobulin light chain (AL) amyloidosis is a rare and underdiagnosed entity.


To characterize patients with AL amyloidosis in Chilean public health centers.

Material and Methods:

We conducted a retrospective, multicenter study. Public centers of the Chilean Monoclonal Gammopathies Cooperative Group were asked to search for patients with AL amyloidosis in their databases. Epidemiological, clinical and laboratory characteristics were evaluated.


Forty-two patients aged 22 to 84 years were found. Twenty four percent had localized AL amyloidosis; 64% had a lambda light chain clone; 47% were associated with multiple myeloma and 9% with non-Hodgkin lymphoma. The most commonly involved organ was the kidney (76%). Serum free light chains were measured in 31% and an echocardiogram was performed in 74% of patients. Seventeen percent of patients received only palliative care, 17% were treated with bortezomib, 21% with thalidomide, and 40% with melphalan. No patient was transplanted. The mean overall survival (OS) of the group was 19 months. The 5-year OS was 28%.


It is important to obtain these realistic, national data to initiate strategies to improve early diagnosis and proper management of this disease.

Keywords : Amyloidosis; Bortezomib; Multiple Myeloma; Paraproteinemias; Transplantation.

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