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Revista médica de Chile

Print version ISSN 0034-9887


CARDEMIL, Daniela et al. Waldenström macroglobulinemia. Experience in 31 patients. Rev. méd. Chile [online]. 2019, vol.147, n.3, pp.275-280. ISSN 0034-9887.


Waldenström macroglobulinemia (WM) is an uncommon indolent B-cell lymphoma, due to the proliferation of lymphoplasmacytic cells, and secretion of a monoclonal IgM protein.


To evaluate the clinical characteristics, management and results of treatment of patients with WM at a public hospital in Chile.

Patients and Methods:

Review of medical records of 31 patients aged 43 to 85 years (16 males) with WM diagnosed between 2002 and 2017. Clinical features and survival were recorded.


All patients had bone marrow compromise, and 31%, extranodal involvement. According to the International Prognostic Score System for WM (IPSSWM) 16, 58 and 26% were at low, intermediate and high risk, respectively. Twenty-five patients (81%) were treated, 32% with plasmapheresis and 36% with rituximab. Four cases (16%) achieved complete remission. Median follow up was 35 months (range 6-159). Estimated overall survival (OS) at 5 and 10 years was 74% and 53%, respectively. According to IPSSWM, the estimated five-year OS was 80, 92 and 39%, for low, intermediate and high-risk patients, respectively.


OS was similar to that reported abroad, except for low risk patients, probably due to the low number of cases and short follow up. An improved survival should be expected with the routine use of immunochemotherapy.

Keywords : Prognosis; Treatment Outcome; Waldenström Macroglobulinemia.

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