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Revista médica de Chile

versión impresa ISSN 0034-9887

Resumen

LEGUES, María Eugenia et al. High risk cytogenetic abnormalities in patients with multiple myeloma. Rev. méd. Chile [online]. 2019, vol.147, n.1, pp.61-64. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872019000100061.

Background:

Cytogenetic abnormalities observed in the bone marrow of patients with multiple myeloma (MM) are an important prognostic factor for risk stratification.

Aim:

To investigate karyotype characteristics and frequency of the high-risk cytogenetic abnormalities t(4;14), t(14;16) and del(17p) in Chilean patients with MM.

Material and Methods:

We studied 30 patients with MM by conventional cytogenetics (CC) and fluorescent in situ hybridization of plasma cells selected using cytoplasmic immunoglobulin staining (cIg-FISH).

Results:

Overall, the two techniques in combination allowed us to identify clonal genetic abnormalities in 47% of patients. The t(4;14) abnormality was observed in 19% of patients, del(17p) was observed in 10% of patients, and t(14;16) was not detected.

Conclusions:

Our results showed frequencies of high-risk abnormalities similar to those reported abroad. Cytogenetic studies should be performed routinely for all MM patients at the moment of diagnosis.

Palabras clave : Chromosome Aberrations; Cytogenetics; Multiple Myeloma.

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