SciELO - Scientific Electronic Library Online

vol.146 issue7Survival of 1,103 Chilean patients with multiple myeloma receiving different therapeutic protocols from 2000 to 2016Waiting times for neurological emergencies in an emergency room author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


Revista médica de Chile

Print version ISSN 0034-9887


FREZ, Carla et al. Extrapyramidal adverse reactions to metoclopramide. A pharmacovigilance survey. Rev. méd. Chile [online]. 2018, vol.146, n.7, pp.876-884. ISSN 0034-9887.


In 2013 the Chilean regulatory sanitary agency issued a warning concerning dose adjustment and use restriction to avoid severe adverse effects of metoclopramide such tardive dyskinesia.


To study dyskinesia type adverse effects in a population using metoclopramide.

Material and Methods:

A cross sectional observational study was conducted among patients pertaining to palliative care and diabetes mellitus programs and consuming 10 mg/day or more of metoclopramide. Patients were interrogated looking for extrapiramidal signs and symptoms using a questionnaire validated by two neurologists.


In 40% of diabetic patients with gastroparesia and 35% of palliative care patients, extrapyramidal adverse reactions to metoclopramide were suspected. Palliative Care patients suffered the largest number of adverse events. The period of use and individual doses of the drug were largely above Chilean regulatory agency recommendations in all cases.


A significant number of patients using metoclopramide could experience extrapyramidal adverse reactions.

Keywords : Drug-Related Side Effects and Adverse Reactions; Dyskinesias; Metoclopramide; Pharmacovigilance.

        · text in Spanish     · Spanish ( pdf )