SciELO - Scientific Electronic Library Online

vol.146 número6Adsorción extracorpórea de citoquinas en el tratamiento del shock séptico refractario. Casos clínicosDaño hepatocelular, proteinuria y autoinmunidad: ¿enfermedad multisistémica o coincidencia de enfermedades? Caso clínico índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google


Revista médica de Chile

versión impresa ISSN 0034-9887


CARTIER R., Luis; PARRA V., Jorge; PUGA, Bárbara  y  CARDEMIL, Daniela. Spinal subacute combined degeneration after intrathecal chemotherapy. Report of two cases. Rev. méd. Chile [online]. 2018, vol.146, n.6, pp.802-807. ISSN 0034-9887.

Intrathecal chemotherapy may be complicated with the development of myelopathies or toxic radiculopathies. This myeloradicular involvement, of toxic character, is unpredictable, since these patients have repeatedly received Intrathecal chemotherapy with the same drugs without apparent injury. The toxic effect should be mainly attributed to Cytarabine and not to methotrexate, since the central nervous system lacks Cytidine deaminase, the enzyme that degrades Cytarabine. We report two patients, an 18-year-old woman and a 16 years old male, who received systemic and intrathecal chemotherapy (methotrexate, cytarabine) for the treatment of an acute lymphoblastic leukemia and developed, in relation to this procedure, a spinal subacute combined degeneration. They had a proprioceptive and motor alteration of the lower extremities and neuroimaging showed selective rear and side spinal cord hyper intensity produced by central axonopathy. Two weeks later the woman developed a quadriplegia and the young man a flaccid paraplegia due to added root involvement.

Palabras clave : Cytarabine; Drug Therapy; Meningeal Neoplasms; Subacute Combined Degeneration.

        · texto en Español     · Español ( pdf )