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Revista médica de Chile

versión impresa ISSN 0034-9887

Resumen

PENA, Camila et al. Diagnostic accuracy of serum protein electrophoresis and free light chain measurements for monoclonal gammopathies. Rev. méd. Chile [online]. 2018, vol.146, n.1, pp.64-67. ISSN 0034-9887.  http://dx.doi.org/10.4067/s0034-98872018000100064.

Background:

International guidelines suggest a screening panel for monoclonal gammopathies that contains serum protein electrophoresis (SPE), free light chain (FLC) measurements and immunofixation. This combination provides the possibility of a timely accurate diagnosis.

Aim:

To evaluate the sensibility of a simple screening panel (SPE + FLC).

Material and Methods:

We analyzed 191 consecutive serum samples of patients with a suspected monoclonal gammopathy (MG).

Results:

Seventy five patients were diagnosed with MG. The sensitivity and specificity of the combination of SPE + FLC for the diagnosis of monoclonal gammopathy were 95% (95% confidence intervals 89-99) and 99% (95% confidence intervals 96-100), respectively.

Conclusions:

We were able to validate the international recommendations on the diagnostic accuracy of this simple combination of two tests in serum for monoclonal gammopathy.

Palabras clave : Diagnosis; Multiple Myeloma; Paraproteinemias.

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