SciELO - Scientific Electronic Library Online

 
vol.145 número7Reflexiones sobre la investigación esencial en ChileEl ‘humor’ de los indios en el saber médico de los siglos XVI-XVII índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Compartir


Revista médica de Chile

versión impresa ISSN 0034-9887

Resumen

CONCHA C., Francisca; SIR P., Teresa; RECABARREN, Sergio E.  y  PEREZ B., Francisco. Epigenetics of polycystic ovary syndrome. Rev. méd. Chile [online]. 2017, vol.145, n.7, pp.907-915. ISSN 0034-9887.  http://dx.doi.org/10.4067/s0034-98872017000700907.

Polycystic ovarian syndrome (PCOS) is an endocrine and metabolic dysfunction, highly prevalent in women in their reproductive years. Hyperandrogenism, oligo-ovulation, polycystic ovarian morphology are the main features of this syndrome. PCOS is a genetic disorder with a multifactorial etiology and has a strong link with environmental components. It is frequently associated with obesity and insulin resistance. Recently, epigenetic mechanisms have been involved in the pathogenesis of PCOS. Several studies showed that methylation in DNA and miRNAs is altered in women with PCOS in blood, serum, adipose tissue, granulose cells and theca. This evidence indicates that women with PCOS have a different epigenetic regulation, which might be triggered by an adverse intrauterine environment or by postnatal environmental elements such as diet and or obesity.

Palabras clave : Epigenomics; Genes, Regulator; Polycystic Ovary Syndrome.

        · texto en Español     · Español ( pdf )