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Revista médica de Chile

Print version ISSN 0034-9887


CHERNE, Pablo Nicolás  and  YOUNG, Pablo. History of the renin-angiotensin system: great men, a great finding. Rev. méd. Chile [online]. 2014, vol.142, n.9, pp.1210-1216. ISSN 0034-9887.

The discovery of the renin-angiotensin-aldosterone system (RAS) was one of the important findings in physiology. Two research groups, in both North and South America, independently discovered that renin released a novel vasopressor agent. The Argentine group named it hypertensin, and called hypertensinogen to its plasma protein substrate. The group from the United States named it angiotonin. In 1958, Braun Menendez and Irvine Page suggested that the peptide´s name should be angiotensin. Development of angiotensin converting enzyme (ACE) inhibitors proved that the RAS is effective in controlling hypertension and heart failure, and in preventing vascular injury in chronic diseases. Both teams, showing that beyond being great investigators they were remarkable persons, shared the merit of the discovery.

Keywords : Angiotensin; History of medicine; Kidney; Physiology.

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