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Revista médica de Chile

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PIRAINO N, PATRICIA; SEPULVEDA N, ANDREA  and  CAVADA CH, GABRIEL. Hashimoto chronic thyroiditis: Retrospective analysis of 228 patients. Rev. méd. Chile [online]. 2010, vol.138, n.7, pp.827-831. ISSN 0034-9887.

Background: Chronic Hashimoto Thyroiditis (CHT) is the main cause of hypothyroidism. Aim: To report a series of patients with CHT. Material and Methods: Retrospective analysis of a series of 27 men aged 38 ± 14 years and 201 women aged 37 ± 16 years, evaluated in the private offces of two of the authors. Results: Fifty six percent of patients only had unspecifc symptoms at the moment of consultation, 50% had a family history of thyroid diseases and only 21% of women had a previous history of goiter. Eighty one percent of patients had clinical or subclinical hypothyroidism, 62% had both antithyroglobulin and antithyroid peroxidase positive antibodies and 13% had both antibodies negative. Only 1.4% of patients had a normal thyroid ultrasound examination. Patients were treated with levothyroxine at a mean dosage of 75 µg/day and 53% achieved an adequate TSH level. Six of ten patients operated due to nodules had a papillary carcinoma. Conclusions: CHT should be sought in the general population, especially those with a family history of thyroid disease. Thyroid ultrasound is seldom normal in patients with CHT. Thyroid substitution should be monitored periodically to achieve adequate TSH levels.

Keywords : Hashimoto disease; Hypothyroidism; Thyrotropin.

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