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Revista médica de Chile

Print version ISSN 0034-9887


DE LA SOTTA F, Pilar; ROMERO G, William  and  GONZALEZ B, Sergio. Skin biopsy for the diagnosis of nervous system diseases. Rev. méd. Chile [online]. 2008, vol.136, n.8, pp.1047-1055. ISSN 0034-9887.

Skin biopsy is a powerful diagnostic tool in Dermatology. Its use has been extended to other medical specialties, aüowing the diagnosis of several diseases that previously required complex and high risk diagnostic procedures. Skin contains numerous cell types, including blood vessels and peripheral nerves and represents a window to the systemic circulation and nervous system. In this review we discuss the use of skin biopsy to diagnose nervous system diseases in which patients do not exhibit any clinical cutaneous manifestations. We review the usefulness of skin biopsy in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopaty (CADASIL), some lysosomal storage diseases, Lafora disease and in peripheral neuropathies.

Keywords : CADASIL; Diagnostic techniques; surgical, biopsy; Lafora disease; Lysosomal storage.

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