SciELO - Scientific Electronic Library Online

 
vol.136 número6Fuentes de contaminación intradomiciliaria y enfermedad respiratoria en jardines infantiles y salas cunas de Temuco y Padre Las Casas, ChileEstatuto ontológico y ético del feto anencefálico: Una perspectiva filosófica índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

Compartir


Revista médica de Chile

versión impresa ISSN 0034-9887

Resumen

MENNICKENT C, Sigrid; BRAVO D, Marisol; CALVO M, Carlos  y  AVELLO L, Marcia. Pleiotropic effects of statins . Rev. méd. Chile [online]. 2008, vol.136, n.6, pp.775-782. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872008000600014.

Results of numerous epidemiologic studies indicate that elevated serum cholesterol, especially the LDL fraction, is a major cause of coronary heart disease (CHD). Epidemiologic and angiographic evidence from primary and secondary prevention studies involving several HMG-CoA reducíase inhibitors (statins) indicate that  decreasing elevated serum cholesterol concentration (specifically LDL-cholesterol) can reduce the incidence of CHD and/or progression of atherosclerosis and results in a decrease in associated morbidity and mortality. It has been estimated that each 1% reduction in LDL-cholesterol concentration may result in a 1% decrease in the incidence of CHD. Furthermore, an analysis of pooled data from primary and secondary prevention studies found that treatment with a statin for a median duration of 5.4 years was associated with a 31% and 21% reduction in the risk of major coronary events and total mortality, respectively. This paper deals with the pharmacology of statins, specially with the pleiotropic effects ofthese drugs

Palabras clave : Coronary disease; Hydroxymethylglutaryl-CoA reductase inhibitors; Intracellular signalingpeptides and proteins.

        · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons