SciELO - Scientific Electronic Library Online

 
vol.134 issue2Suspicion of systemic diseases through nails abnormalitiesProfessional responsibility: maximal, minimal, excellence and veracity author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Revista médica de Chile

Print version ISSN 0034-9887

Abstract

EYZAGUIRRE C, Francisca  and  CODNER, Ethel. Insulin analogues: searching for a physiological replacement. Rev. méd. Chile [online]. 2006, vol.134, n.2, pp.239-250. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872006000200016.

Insulin analogues, developed by molecular engineering, have structural changes in the A and B insulin chains. These modifications change their action profile, rendering insulin replacement closer to physiology. Rapid acting analogues like lispro, aspart and glulisine, are absorbed rapidly from the subcutaneous tissue to the circulation. In addition, two long acting insulin analogues have been developed: glargine and detemir. The combination of a long acting insulin, to maintain baseline levels, and multiple daily doses of a rapid acting analogue are the mainstay of basal-bolus therapy. Multiples studies have compared human insulin (NPH and regular) with insulin analogues in patients with type 1 or 2 diabetes mellitus, showing an improvement in the metabolic control, fewer hypoglycemic events and better quality of life. In summary, insulin analogues offer new therapeutic options and allow an individualized intensive treatment

Keywords : Diabetes mellitus, insulin dependent; Insulin; Insulin, long acting; Pro insulin.

        · text in Spanish     · Spanish ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License