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Revista médica de Chile

Print version ISSN 0034-9887

Abstract

IBARRA V, Humberto; RIEDEMANN G, Stella  and  TOLEDO A, Claudio. Hepatitis A and E virus antibodies in Chilean children of low socioeconomic status. A one year follow-up study. Rev. méd. Chile [online]. 2006, vol.134, n.2, pp.139-144. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872006000200001.

Background: The seroprevalence of antibodies against hepatitis A virus (HAV) is decreasing in many Latin American countries, along with improvements in sanitary standards. However, there is no information available about low socioeconomic status (LSE) populations. Aim: To assess the evolution of hepatitis A and E virus antibodies in a cohort of LSE Chilean children. Material and methods: One hundred sixty eight children aged four years, 97 males, coming from public primary care clinics, were studied. Two blood samples were obtained with an interval of one year. Anti-HAV and anti-hepatitis E virus (HEV) antibodies, were detected by ELISA using Abbott kits. Results: Anti-HAV was positive in 19 children (11.3%). After one year of follow-up, only 10 children had sustained reactivity (52.6%). Fourteen children, initially negative, became positive during the follow up (9.4%). Antibody titers to HAV were significantly higher in samples that remained positive, compared with those that lost reactivity. Anti-HEV was found positive in two children (1.2%). One remained positive and the other became negative. Conclusions: In this cohort of LSE Chilean children, the prevalence to antibodies against HAV and HEV is low. Follow-up detected loss of reactivity to HAV in nearly one half of the children, probably related to lower antibody levels

Keywords : Hepatitis A; Hepatitis A antibodies; Hepatitis E; Hepatitis, viral, human.

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