SciELO - Scientific Electronic Library Online

 
vol.132 número1Marcadores genéticos (HLA) y perfil de auto-anticuerpos en una familia mapuche con un caso de diabetes tipo 1Cintigrama renal DMSA en niños con primera pielonefritis aguda: correlación con exámenes de laboratorio, ecografía y la presencia de reflujo vésico ureteral índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

Compartir


Revista médica de Chile

versión impresa ISSN 0034-9887

Resumen

DE ARETXABALA U, Xabier et al. Neoadjuvant chemoradiotherapy in gallbladder cancer. Rev. méd. Chile [online]. 2004, vol.132, n.1, pp.51-57. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872004000100008.

Gallbladder cancer is generally associated with a poor prognosis, being local recurrence the main pattern of failure. Aim: To evaluate neoadjuvant chemoradiation as a means to improve the prognosis in gallbladder cancer. Patients and methods: Twenty three gallbladder cancer patients were prospectively treated between June 1993 and September 1999 in the Temuco Regional Hospital. Eighteen (82%) patients had subserosal infiltration, while three (13%) had serosal and two (9%) adipose tissue infiltration. Chemotherapy was done with 5-fluorouracil in continuous infusion during 5 days at day 1 and 28 of treatment. Radiotherapy consisted in a total dose of 4500 cGy, divided in 25 sessions. Patients' survival was compared with a series of 19 patients not subjected to chemoradiation, formerly treated at the institution. Results: Twenty patients had hematological problems secondary to the therapy. Leucopenia and thrombocytopenia were the most common toxic effects and eight had leucopenia under 2.0 x 103 during the treatment course. Chemoradiation delayed surgical treatment in eight patients. After the chemoradiation protocol, seven patients were excluded from surgical treatment and 14 patients underwent resection. Three of the latter (11%) had liver involvement and four (14%) had lymph node involvement. Among the patients who underwent resection, five are still alive with a follow up of 43.8 months. Treated patients had a worst actuarial survival than subjects not treated with chemoradiation. Conclusions: In this series of patients chemoradiation had no positive effect and a potentially detrimental effect in patients with gallbladder cancer (Rev Méd Chile 2004; 132: 51-7).

Palabras clave : Chemotherapy; adjuvant; Gallbladder neoplasms; Radiotherapy; adjuvant.

        · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons