SciELO - Scientific Electronic Library Online

 
vol.131 issue7Clinical features and gender identity among eating disordered patients subtypesEvidence for association between microsatellite markers located on 6p22-25 and nonsyndromic cleft lip palate using the case-parents trio design in the Chilean population author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Revista médica de Chile

Print version ISSN 0034-9887

Abstract

FOLATRE B, sabel et al. Infections caused by Varicella Zoster virus in cancer bearing children aged less than 15 years old. Rev. méd. Chile [online]. 2003, vol.131, n.7, pp.759-764. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872003000700007.

Background: Infections caused by Varicella Zoster virus in children with cancer have a high rate of complications and mortality. Aim: To report the outcome of this infection in children with cancer. Patients and methods: Retrospective analysis of medical records of 216 children aged less than 15 years old with the diagnosis of an hematological or solid tumor, admitted to the National Program of Antineoplastic Drugs (PINDA). Results: Eighty seven children had a Varicella Zoster virus infections, 73 (84%) had varicella, 8 (9%) had herpes zoster and 6 (7%) had varicella and herpes zoster. Ninety four percent acquired the infection during antineoplastic treatment and 78% received Acyclovir as antiviral therapy. During a nosocomial outbreak of varicella, three patients with an Acute Lymphoblastic leukemia died in the initial phase of chemotherapy, in spite of an early administration of Acyclovir. No patient with herpes zoster died. Conclusions: The incidence of varicella was higher in children with leukemia or lymphoma than in children with other types of cancer. Virus reactivation was uncommon and had a benign course. Varicella mortality in these children could be favorably modified through an active immunization of immunocompetent children (Rev Méd Chile 2003; 133: 759-64)

Keywords : Acyclovir; Herpes Zoster; Neoplasms; Varicellovirus.

        · text in Spanish

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License