SciELO - Scientific Electronic Library Online

vol.131 issue6Progression from intestinal metaplasia to adenocarcinoma in Barrett's esophagus: Usefulness of endoscopic surveillanceEffect of ipratropium bromide on lung dynamic hyperinflation in patients with chronic obstructive lung disease (COPD author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Revista médica de Chile

Print version ISSN 0034-9887


BALCAZAR-MUNOZ, Blanca R; MARTINEZ-ABUNDIS, Esperanza  and  GONZALEZ-ORTIZ, Manuel. Effect of oral inulin administration on lipid profile and insulin sensitivity in dyslipidemic obese subjects. Rev. méd. Chile [online]. 2003, vol.131, n.6, pp.597-604. ISSN 0034-9887.

Background: Inulin is a non absorbable polysaccharide with prebiotic effects, whose influence on blood lipids or insulin sensitivity is not well known. Aim: To assess the effect of oral administration of inulin on lipid profile and insulin sensitivity in dyslipidemic obese subjects. Material and Methods: A clinical trial, double blind, randomized with placebo was carried out in 12 obese, hypertrygliceridemic and hypercholesterolemic subjects between 19 and 32 years old. The subjects were randomized to receive 7 g/day of inulin or placebo in the morning, during 4 weeks. Biochemical and metabolic profiles and euglycemic-hyperinsulinemic clamp technique for assessing insulin sensitivity, before and after pharmacological intervention were performed. Results: After inulin administration, there was a significant reduction of total cholesterol (248.7±30.5 and 194.3±39.8 mg/dL; p=0.028), low density lipoprotein (LDL), cholesterol (136.0±27.8 and 113.0±36.2 mg/dL; p= 0.028), very low density lipoproteins (VLDL) (45.9±18.5 and 31.6±7.2 mg/dL; p=0.046) and trygliceride concentrations (235.5±85.9 and 171.1±37.9 mg/dL; p=0.046). No effect of inulin on insulin sensitivity was observed. Conclusions: The oral inulin administration reduced total cholesterol, LDL cholesterol, VLDL and trygliceride levels in dyslipidemic and obese subjects, without modifications in the insulin sensitivity. (Rev Méd Chile 2003; 131: 597-604)

Keywords : Hyperlipidemia; Insulin resistance; Inulin; Obesity.

        · text in Spanish


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License