SciELO - Scientific Electronic Library Online

vol.129 issue6Prediction of coronary angioplasty success using different coronary artery lesion socoresClinical diagnosis of Clostridium Difficile diarrhea author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Revista médica de Chile

Print version ISSN 0034-9887


PEREZ-BRAVO, Francisco et al. Auto-antibody levels and history of breast-feeding in type 1 diabetic patients. Rev. méd. Chile [online]. 2001, vol.129, n.6, pp.611-619. ISSN 0034-9887.

Background: Islet cell-specific autoantibodies such as islet cell antibody (ICA), antiinsulin (IAA), anti-glutamic acid decarboxylase (GAD) and anti-tyrosine phosphatase (IA2) can be present in patients with type I diabetes. Breast feeding duration and the early exposure to milk substitutes are environmental factors associated to etiology of type 1 diabetes. Aim To study the frequency of the anti-GAD, anti-IA-2 e ICA antibodies in Chilean type 1 diabetic patients and determine the possible modulator effect of the breast feeding. Patients and methods: One hundred thirty four type I diabetic patients, aged one to 15 years old, were studied at the moment of their diagnosis. Patients were classified according to the duration of exclusive breast feeding. IA-2 and GAD were determined by radio immuno assay and ICA by means of indirect immunofluorescence. Results: Subjects with three months or less and those with more than three months of breast feeding were positive for ICA in 78.8 and 90.6% of cases respectively, for GAD in 75 and 54.6% of cases respectively (p=0.024) and for IA-2 in 73 and 43.8% of cases respectively (p=0.001). All three antibodies were positive in 53.9 and 21.8% of children with less or more than three months of breast feeding (p=0.001). Conclusion: Both IA-2 and GAD antibodies are less frequently positive in type 1 diabetic patients who have been breast fed for more than three months. These findings suggest a possible attenuating role of exclusive breast feeding on pancreatic aggression events in patients with type 1 diabetes (Rev Méd Chile, 2001; 129: 611-9)

Keywords : Antibodies; Breast feeding; Diabetes mellitus; insulin-dependent.

        · text in Spanish


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License