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Revista médica de Chile

versão impressa ISSN 0034-9887

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CORTES M, Fanny et al. Frequency of neural tube defects in Chilean maternity hospitals during 1999. Rev. méd. Chile [online]. 2001, vol.129, n.3, pp.277-284. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872001000300007.

Background: Fortification of wheat flour with folic acid in Chile, started in January 2000. This fortification should decrease the incidence of neural tube defects. Aim: To study the incidence of neural tube defects among Chilean newborns, during 1999. Material and methods: The records of all newborns and stillbirths with a birth weight over 500 g from 9 public maternity hospitals in Santiago in 1999, were reviewed. All neural tube defects, associated or not to other malformations were taken into account. Results: During the study period, 59.627 newborns and 455 stillbirths were analyzed. The global incidence of neural tube defects was 1.56 per 1.000 born (57% women, 42% men and 1% ambiguous sex). Spina bifida was the most frequent neural tube defect found. Conclusion: These baseline data will be useful to assess the impact of folic acid fortification of wheat flour. (Rev Méd Chile 2001; 129: 277-84).

Palavras-chave : Abnormalities; Folic acid; Neural tube defects; Wheat.

        · texto em Espanhol

 

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