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Revista médica de Chile

Print version ISSN 0034-9887


SOZA R, Alejandro et al. Hepatotoxixity associated to the use of amoxicillin-clavulanic acid. Rev. méd. Chile [online]. 1999, vol.127, n.12, pp.1487-1491. ISSN 0034-9887.

We report a 72 years old diabetic male that, after the use of combined amoxicillin-clavulanic acid, developed pruritus and jaundice. Liver function tests showed serum total bilirubin of 4.3 mg/dL aspartate aminotransferase 140 U/l (normal <35 U/L), alanine aminotransferase 470 U/L (normal <40) and alkaline phosphatases of 400 U/L (normal <100). Serology for hepatitis A, B and C viruses was negative, ERCP showed a normal biliary tree and liver biopsy disclosed a cholestatic hepatitis. Ursodeoxycholic was started to relieve pruritus. Liver function tests improved shortly thereafter, suggesting that this drug may be useful in the treatment of drug induced cholestasis.

Keywords : Amoxicillin; Cholestasis, intrahepatic; Clavulanic acids; Hepatitis, toxic; Ursodeoxycholic acid.

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