SciELO - Scientific Electronic Library Online

 
vol.126 número7La terapia génica y sus aplicacionesProposición de consenso para el uso de yodo 131 en el tratamiento de la tirotoxicosis y el cáncer del tiroides índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

Compartir


Revista médica de Chile

versión impresa ISSN 0034-9887

Resumen

SANTOLAYA DE P, María Elena. Superantígenos y su rol en enfermedades infecciosas. Rev. méd. Chile [online]. 1998, vol.126, n.7, pp.846-854. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98871998000700014.

The role of superantigens in infectious diseases Exogenous antigens are presented to T lymphocytes through a mechanism that ensures a high recognition specificity. On the other hand, recently described superantigens are particles that do not follow the processing or presentation route and do not bind to a specific region of T lymphocyte receptors, as conventional antigens. These particles bind to a large number of T lymphocytes, generating a disproportionate and unspecific immune response. Two types of superantigens have been described. Endogenous superantigens, that are transported in the host genoma, and that are involved in clonal depletion and immunological tolerance phenomena. Exogenous superantigens, mostly bacterial toxins, are involved in several diseases. There is evidence that these antigens participate in diseases such as Kawasaki disease, toxic shock caused by Staphylococcus aureus, rheumatoid arthritis, HIV infection and Streptococcus pyogenes infections

Palabras clave : Superantigens; Receptors, antigen, T-cell, alpha-beta; Infections diseases; Bacterial toxins.

        · texto en Español

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons