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Referencias del artículo

SIMOPOULOS, ARTEMIS P. Omega-3 Fatty Acids and Antioxidants in Edible Wild Plants. Biol. Res. [online]. 2004, vol.37, n.2, pp. 263-277. ISSN 0716-9760.  http://dx.doi.org/10.4067/S0716-97602004000200013.

    1. SIMOPOULOS AP (1991) Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr 54: 438-463 [ Links ]

    2. SIMOPOULOS AP (1986) Kifer RR, Martin RE (eds). Health Effects of Polyunsaturated Fatty Acids in Seafoods. Orlando, FL, Academic Press. [ Links ]

    3. GALLI C, SIMOPOULOS AP (eds) (1989) Dietary w3 and w6 Fatty Acids. Biological Effects and Nutritional Essentiality. New York, Plenum Press [ Links ]

    4. SIMOPOULOS AP, KIFER RR, MARTIN RE, BARLOW SM (eds) (1991). Health Effects of w3 Polyunsaturated Fatty Acids in Seafoods. World Rev Nutr Diet 66: 1-592 [ Links ]

    5. GALLI C, SIMOPOULOS AP, TREMOLI E (eds) (1994) Fatty Acids and Lipids: Biological Aspects. World Rev Nutr Diet 75: 1-197 [ Links ]

    6. GALLI C, SIMOPOULOS AP, TREMOLI E (eds) (1994) Effects of Fatty Acids and Lipids in Health and Disease. World Rev Nutr Diet 76: 1-152 [ Links ]

    7. SALEM N JR, SIMOPOULOS AP, GALLI C, LAGARDE M, KNAPP HR (eds) (1996) Fatty Acids and Lipids from Cell Biology to Human Disease. Lipids 31(suppl): S1-S326 [ Links ]

    8. SIMOPOULOS AP (1997) W-3 fatty acids in the prevention-management of cardiovascular disease. Can J Physiol Pharmacol 75: 234-239 [ Links ]

    9. LAGARDE M, SPECTOR AA, GALLI C, HAMAZAKI T, KNAPP HR (eds) (1999) Fatty Acids and Lipids from Cell Biology to Human Disease. Lipids 34(suppl): S1-S350 [ Links ]

    10. HAMAZAKI T, OKUYAMA H (2001) Fatty Acids and Lipids _ New Findings. World Rev Nutr Diet 88: 1-260 [ Links ]

    11. BURR ML, FEHILY AM, GILBERT JF, ROGERS S, HOLLIDAY RM, SWEETNAM PM, ELWOOD PC, DEADMAN NM (1989) Effect of changes in fat, fish and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet 2: 757-761 [ Links ]

    12. DE LORGERIL M, RENAUD S, MAMELLE N, SALEN P, MARTIN JL, MONJAUD I, GUIDOLLET J, TOUBOUL P, DELAYE J (1994) Mediterranean a-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet 343: 1454-1459 [ Links ]

    13. SINGH RB, NIAZ MA, SHARMA JP, KUMAR R, RASTOGI V, MOSHIRI M (1997) Randomized, double-blind, placebo-controlled trial of fish oil and mustard oil in patients with suspected acture myocardial infarction. The Indian experiment of infarct survival-4. Cardiovasc Drugs Ther 11: 485-491 [ Links ]

    14. GISSI-Prevenzione Investigators (1999) Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 354: 447-455 [ Links ]

    15. MORRIS MC, SACKS F, ROSNER B (1994) Fish oil to reduce blood pressure: a meta-analysis. Ann Intern Med 120(suppl): 10 [ Links ]

    16. APPEL LJ, MILLER ER, SEIDLER AJ, WHELTON PK (1994) Diet supplementation with fish oils and blood pressure reduction: a meta-analysis. Ann Intern Med 120(suppl): 10 [ Links ]

    17. APPEL LJ, MILLER ER 3rd, SEIDLER AJ, WHELTON PK (1993) Does supplementation of diet with "fish oil" reduce blood pressure? A meta-analysis of controlled clinical trials. Arch Intern Med 153: 1429-1438 [ Links ]

    18. RAHEJA BS, SADIKOT SM, PHATAK RB, RAO MB (1993) Significance of the n-6/n-3 ratio for insulin action in diabetes. Ann N Y Acad Sci 683: 258-271 [ Links ]

    19. CONNOR WE, PRINCE MJ, ULLMANN D, et al. (1993) The hypotriglyceridemic effect of fish oil in adult-onset diabetes without adverse glucose control. Ann N Y Acad Sci 683: 337-340 [ Links ]

    20. DE CATERINA R, CAPRIOLI R, GIANNESSI D, SICARI R, GALLI C, LAZZERINI G, BERNINI W, CARR L, RINDI P (1993) n-3 fatty acids reduce proteinuria in patients with chronic glomerular disease. Kidney Int 44: 843-850 [ Links ]

    21. DONADIO JV JR, BERGSTRALH EJ, OFFORD KP, SPENCER DC, HOLLEY KE (1994) A controlled trial of fish oil in IgA nephropathy. Mayo Neprology Collaborative Group. N Engl J Med 331: 1194-1199 [ Links ]

    22. KREMER JM (1996) Effects of modulation of inflammatory and immune parameters in patients with rheumatic and inflammatory disease receiving dietary supplementation of n-3 and n-6 fatty acids. Lipids 31(suppl): S243-S247 [ Links ]

    23. STENSON WF, CORT D, RODGERS J, BURAKOFF R, DESCHRYVER-KECSKEMETI K, GRAMLICH TL, BEEKEN W (1992) Dietary supplementation with fish oil in ulcerative colitis. Ann Intern Med 116: 609-614 [ Links ]

    24. BELLUZZI A, BRIGNOLA C, CAMPIERI M, PERA A, BORSCHI S, MIGLIOLI M (1996) Effect of an enteric-coated fish-oil preparation on relapses in Crohn's disease. N Engl J Med 1334: 1557-1560 [ Links ]

    25. SHAHAR E, FOLSOM AR, MELNICK SL, TOCKMAN MS, COMSTOCK GW, GENNARO V, HIGGINS MW, SORLIE PD, KO WJ, SZKLO M (1994) Dietary n-3 polyunsaturated fatty acids and smoking-related chronic obstructive pulmonary disease. Atherosclerosis Risk in Communities Study Investigators. New Engl J Med 331: 228-233 [ Links ]

    26. AMES BM (1983) Dietary carcinogens and degenerative diseases. Science 221: 1256-1263 [ Links ]

    27. GEY KF (1990) The antioxidant hypothesis of cardiovascular disease: epidemiology and mechanisms. Biochem Soc Trans 18: 1041-1045 [ Links ]

    28. STEINBERG D (1991) Antioxidants and atherosclerosis: a current assessment. Circulation 84: 1420-1425 [ Links ]

    29. STEINBERG D, PARTHASARATHY S, CAREW TE, KHOO JC, WITZTUM JL (1989) Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity. New Engl J Med 320: 915-924 [ Links ]

    30. GUTTERIDGE JM, HALLIWELL B (2000) Free radicals and antioxidants in the year 2000: a historical look to the future. Ann NY Acad Sci 899: 136-147 [ Links ]

    31. HALLIWELL B (1999) Antioxidant defence mechanisms: from the beginning to the end (of the beginning). Free Radic Res 31: 261-272 [ Links ]

    32. CARR A, FREI B (1999) Does vitamin C act as a pro-oxidant under physiological conditions? FASEB J 13: 1007-1024 [ Links ]

    35. HALLIWELL B (2000) The antioxidant paradox. Lancet 355: 1179-1180 [ Links ]

    36. McCALL MR, FREI B (1999) Can antioxidant vitamins materially reduce oxidative damage in humans? Free Radic Biol Med 26: 1034-1053 [ Links ]

    41. MILLER NJ, RICE-EVANS CA (1996) Spectrophotometric determination of antixodant activity. Redox Rep 12: 161-168 [ Links ]

    42. BENZIE IFF, STRAIN JJ (1996) The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem 239: 70-76 [ Links ]

    43. CAO G, ALESSIO HM, CUTLER RG (1993) Oxygen-radical absorbance capacity assay for antioxidants. Free Radic Biol Med 14: 303-311 [ Links ]

    44. EATON SB, KONNER M (1985) Paleolithic nutrition. A consideration of its nature and current implications. N Engl J Med 312: 283-289 [ Links ]

    45. SIMOPOULOS AP (1995) Evolutionary aspects of diet: fatty acids, insulin resistance and obesity. In: VanItallie TB, Simopoulos AP (eds). Obesity: New Directions in Assessment and Management. Philadelphia, Charles Press, 241-261 [ Links ]

    46. SIMOPOULOS AP (1999) Genetic variation and evolutionary aspects of diet. In: Papas AM (ed). Antioxidant Status, Diet, Nutrition and Health. Boca Raton, CRC Press, 65-88 [ Links ]

    47. SIMOPOULOS AP (ed) (1995) Plants in Human Nutrition. World Rev Nutr Diet. Basel, Karger, vol. 77 [ Links ]

    48. Report of the National Cholesterol Education Program Expert Panel on detection, evaluation and treatment of high blood cholesterol in adults (1988) Arch Intern Med 148: 36-69 [ Links ]

    49. SIMOPOULOS AP (2001) Evolutionary aspects of diet and essential fatty acids. In: Hamazaki T, Okuyama H (eds). Fatty Acids and Lipids - New Findings. World Rev Nutr Diet 88: 18-27 [ Links ]

    52. SANDERS TAB (2000) Polyunsaturated fatty acids in the food chain in Europe. Am J Clin Nutr 71(suppl): S176-S178 [ Links ]

    53. SUGANO M, HIRAHARA F (2000) Polyunsaturated fatty acids in the food chain in Japan. Am J Clin Nutr 71(suppl): S189-S196 [ Links ]

    54. CRAWFORD MA (1968) Fatty acids in free-living and domestic animals. Lancet 1: 1329-1333 [ Links ]

    55. VAN VLIET T, KATAN MB (1990) Lower ratio of n-3 to n-6 fatty acids in cultured than in wild fish. Am J Clin Nutr 51: 1-2 [ Links ]

    56. SIMOPOULOS AP, SALEM N JR (1989) n-3 fatty acids in eggs from range-fed Greek chickens. N Engl J Med 321: 1412 [ Links ]

    57. SIMOPOULOS AP, SALEM N JR (1986) Purslane: a terrestrial source of omega-3 fatty acids. N Engl J Med 315: 833 (letter) [ Links ]

    58. SIMOPOULOS AP, NORMAN HA, GILLASPY JE (1995) Purslane in human nutrition and its potential for world agriculture. World Rev Nutr Diet 77: 47-74 [ Links ]

    59. SIMOPOULOS AP, LEAF A, SALEM N JR (1999) Essentiality of and recommended dietary intakes for omega-6 and omega-3 fatty acids. Ann Nutr Metab 43: 127-130 [ Links ]

    60. CRAWFORD M, GALLI C, VISIOLI F, RENAUD S, SIMOPOULOS AP, SPECTOR AA (2000) Role of plant-derived omega-3 fatty acids in human nutrition. Ann Nutr Metab. 44: 263-265 [ Links ]

    61. INDU M, GHAFOORUNISSA (1992) n-3 fatty acids in Indian diets _ comparison of the effects of precursor (alpha-linolenic acid) vs product (long chain n-3 polyunsaturated fatty acids). Nutr Res 12: 569-582 [ Links ]

    62. EMKEN EA, ADLOT RO, GULLEY RM (1994) Dietary linoleic acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males. Biochem Biophys Acta 1213: 277-288 [ Links ]

    63. MANTZIORIS E, JAMES MJ, GIBSON RA, CLELAND LG (1994) Dietary substitution with an a-linolenic acid-rich vegetable oil increases eicosapentaenoic acid concentrations in tissues. Am J Clin Nutr 59: 1304-1309 [ Links ]

    64. McLENNAN PL (1993) Relative effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on cardiac arrhythmias in rats. Am J Clin Nutr 57: 207-212 [ Links ]

    65. REAVEN P, PARTHASARATHY S, GRASSE BJ, MILLER E, ALMAZAN F, MATTSON FH, KHOO JC, STEINBERG D, WITZTUM JL (1991) Feasibility of using an oleate-rich diet to reduce the susceptibility of low-density lipoprotein to oxidative modification in humans. Am J Clin Nutr 54: 701-706 [ Links ]

    66. ABBEY M, BELLING GB, NOAKES M, HIRATA F, NESTEL PJ (1993) Oxidation of low-density lipoproteins: intraindividual variability and the effect of dietary linoleate supplementation. Am J Clin Nutr 57: 391-398 [ Links ]

    67. RENAUD S (1990) Linoleic acid, platelet aggregation and myocardial infarction. Atherosclerosis 80: 255-256 [ Links ]

    68. RENAUD S, MORAZAIN R, GODSEY F, DUMONT E, THEVENON C, MARTIN JL, MENDY F (1986) Nutrients, platelet function and composition in nine groups of French and British farmers. Atherosclerosis 60: 37-48 [ Links ]

    69. RENAUD S, GODSEY F, DUMONT E, THEVENON C, ORTCHANIAN E, MARTIN JL (1986) Influence of long-term diet modification on platelet function and composition in Moselle farmers. Am J Clin Nutr 43: 136-150 [ Links ]

    70. BUDOWSKI P, CRAWFORD MA (1985) Alpha-linolenic acid as a regulator of the metabolism of arachidonic acid: dietary implications of the ratio of n-6: n-3 fatty acids. Proc Nutr Soc 44: 221-229 [ Links ]

    71. BERRY EM, HIRSCH J (1986) Does dietary linoleic acid influence blood pressure? Am J Clin Nutr 44: 336-340 [ Links ]

    72. ASCHERIO A, RIMM EB, GIOVANNUCCI EL, SPIEGELMAN D, STAMPFER M, WILLETT WC (1996) Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States. BMJ 313: 84-90 [ Links ]

    73. DEUEL HJ, JR (1951) The Lipids, Vol. 1. Interscience Publishers, Inc.: New York, p. 18 [ Links ]

    74. LEDGER HP (1968) Body composition as a basis for a comparative study of some East African mammals. Symp Zool Soc London 21: 289-310 [ Links ]

    75. WO CKW, DRAPER HH (1975) Vitamin E status of Alaskan Eskimos. Am J Clin Nutr 28: 808-813 [ Links ]

    76. CRAWFORD MA, GALE MM, WOODFORD MH (1969) Linoleic acid and linolenic acid elongation products in muscle tissue of Syncerus caffer and other ruminant species. Biochem J 115: 25-27 [ Links ]

    77. TINOCO J (1987) Dietary requirements and functions of alpha-linolenic acid in animals. Prog Lipid Res 21: 1-45 [ Links ]

    78. SIMOPOULOS AP (1988) Terrestrial sources of omega-3 fatty acids: purslane. In: Quebedeaux B, Bliss FA (eds). Horticulture and Human Health. Contributions of Fruits and Vegetables. Prentice Hall, Englewood Cliffs, NJ pp. 93-107 [ Links ]

    79. SIMOPOULOS, AP, NORMAN HA, GILLASPY JE, DUKE JA (1992) Common purslane: a source of omega-3 fatty acids and antioxidants. J Am College Nutr 11: 374-382 [ Links ]

    80. ZEGHICHI S, KALLITHRAKA S, SIMOPOULOS AP (2000) Antioxidant content and fatty acid composition of Corchorus olitorius and Cichorium spinosum. Program and Abstract Book. Fourth International Conference on Nutrition and Fitness, Ancient Olympia, Greece, May Pp. 103-104 [ Links ]

    81. ZEGHICHI S, KALLITHRAKA S, SIMOPOULOS AP, KYPRIOTAKIS Z (2003) The nutritional composition of selected wild plants in the diet of Crete. In: Simopoulos AP, Gopalan C (eds). Plants in Human Health and Nutrition Policy. World Rev Nutr Diet. Karger, Basel, 91: 22-40 [ Links ]

    82. ZEGHICHI S, KALLITHRAKA S, SIMOPOULOS AP (2003) Nutritional composition of Molokhia (Corchorus olitorius) and Stamnagathi (Cichoium spinosum). In: Simopoulos AP, Gopalan C (eds). Plants in Human Health and Nutrition Policy. World Rev Nutr Diet. Karger, Basel, 91: 1-21 [ Links ]

    83. SIMOPOULOS AP, GOPALAN C (eds) Plants in Human Health and Nutrition Policy. World Rev Nutr Diet. Karger, Basel, vol. 91 [ Links ]

    84. NORTON HH, HUNN ES, MARTINSEN CS, KEELY PB (1984) Vegetable food products of the foraging economies of the Pacific Northwest. Ecol Food & Nutr 14: 219-228 [ Links ]

    85. UNITED STATES DEPARTMENT OF AGRICULTURE (1986) Provisional table on the content of omega-3 fatty acids and other fat components in selected foods. In: Simopoulos AP, Kifer RR, Martin RE (eds). Health Effects of Polyunsaturated Fatty Acids in Seafoods. Orlando, FL, Academic Press [ Links ]

    86. FINCKH BF, KUNERT KJ (1985) Vitamin C and E: An antioxidative system against herbicide-induced lipid peroxidation in higher plants. J Agri Food Chem 33: 574-577 [ Links ]

    87. SPURGEON SLl, PORTER JW (1980) Carotenoids. In: Stumpf PK (ed). The Biochemistry of Plants, Lipids: Structure and Function. New York, Academic Press, vol. 40, pp 419-483 [ Links ]

    88. GOODWIN TW (1976) Distribution of carotenoids. In Goodwin TW (ed): Chemistry and Biochemistry of Plant Pigments. New York, Academic Press, vol. 1, pp. 127-142 [ Links ]

    89. JONES DP, HAGEN TM, WEBER R, WIERZBICKA GT, BONKOVSKY HL (1989) Oral administration of glutathione (GSH) increases plasma GSH concentrations in humans (abstract). FASEB J 3: A1250 [ Links ]

    90. JONES DP, COATES RJ, FLAGG EW, et al. (1992) Glutathione in Foods listed in the National Cancer Institute's Health Habits and History Food Frequency Questionnaire. Nutr Cancer 17: 57-75 [ Links ]

    91. BLOCK G, DRESSER CM, HARTMAN AM, CARROLL MD (1985) Nutrient sources in the American diet: Quantitative data from the NHANES II Survey. I. Vitamins and Minerals. Am J Epidemiol 122: 13-26 [ Links ]

    92. BLOCK G, DRESSER CM, HARTMAN AM, CARROLL MD (1985) Nutrient sources in the American diet: Quantitative data from the NHANES II Survey. Macronutrients and Fats. Am J Epidemiol 122: 27-40 [ Links ]

    93. MANNERVIK B, CARLBERG I, LARSON K (1989) Glutathione: General review of mechanisms of action. In Dolphin D, Avramovic O, Pulson R (eds). Glutathione. Chemical, Biochemical and Medical Aspects. New York, Wiley, pt. A, pp 475-516 [ Links ]

    94. WATTENBERG LW (1985) Perspectives in cancer research. Chemoprevention of cancer. Cancer Res 45: 1-8 [ Links ]

    95. FREI B, ENGLAND L, AMES BN (1989) Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci USA 86: 6377-6381 [ Links ]

    96. BENDICH A (1985) Antioxidant micronutrients in immune responses. In: Bendich A, Chandra RK (eds). Micronutrients and Immune Functions. New York, New York Academy of Sciences, vol. 587, pp 169-180 [ Links ]

    97. FREI B, STOCKER R, AMES BN (1988) Antioxidant defenses and lipid peroxidation in human blood. Proc Natl Acad Sci USA 85: 9748-9752 [ Links ]

    98. OLEINICK NL, XUE L, FRIEDMAN LR, DONAHUE LL, BIAGLOW JE (1988) Inhibition of radiation-induced DNA-protein cross-link repair by glutathione depletion with L-buthionine sulfoximine. NCI Monogr 6: 225-229 [ Links ]

    99. FUCHS JA (1989) Glutaredoxin. In: Dolphin D, Avramovic O, Poulson R (eds). Glutathione. Biochemical and Medical Aspects. New York, Wiley, pt B, pp 551-570 [ Links ]

    100. FURUKAWA T, MEYDANI SN, BLUMBERG JB (1987) Reversal of age-associated decline in immune responsiveness by dietary glutathione supplementation in mice. Mech Ageing Dev 38: 107-117 [ Links ]

    101. BUHL R, HOLROYD KJ, MASTRANGELI A, CANTIN AM, JAFFE HA, et al. (1989) Systematic glutathione deficiency in symptom-free HIV-seropositive individuals. Lancet ii: 1294-1298 [ Links ]

    102. FLAGG EW, COATES RJ, JONES DP, ELEY JW, GUNTER EW, JACKSON B, GREENBERG RS (1993) Plasma total glutathione in humans and its association with demographic and health-related factors. Br J Nutr 70: 797-808 [ Links ]

    103. McCAY PB (1985) Vitamin E. Interactions with free radicals and ascorbate. Ann Rev Nutr 5: 323-340 [ Links ]

    104. RENNEBERG H (1982) Glutathione metabolism and possible biological roles in the higher plant. Phytochemistry 21: 2771-2781 [ Links ]

    105. RENNEBERG H (1987) Aspects of glutathione function and metabolism in plants. In: Von Wettstein D, Chua NH (eds). Plant Molecular Biology. New York, Plenum Press, pp 279-292 [ Links ]

    106. HATZIOS KK, BORMANN JF (eds) (1989) Proceedings 1989 Annual Symposium South ASPP. Glutathione Synthesis and Function in Higher Plants. Physiol Plant 77: 447-471 [ Links ]

    107. KOIKE S, PATTERSON BD (1988) Diurnal variation of glutathione levels in tomato seedlings. Hort Sci 23: 713-714 [ Links ]

    108. SCHUPP R, RENNENBERG H (1988) Diurnal changes in the glutathione content of spruce needles (Picea abies L.) Plant Sci 57: 113-117 [ Links ]

    109. EARNSHAW BA, JOHNSON MA (1987) Control of wild carrot somatic embryo development by antioxidants. Plant Physiol 85: 273-276 [ Links ]

    110. DE KOK LJ, DE KAN PJL, TANCZOS OG, KUIPER PJC (1981) Sulphate-induced accumulation of glutathione and frost-tolerance of spinach leaf tissue. Physiol Plant 53: 435-438 [ Links ]

    111. WISE RR, NAYLOR AW (1987) Chilling-enhanced photooxidation. The peroxidative destruction of lipids during chilling injury to photosynthesis and ultrastructure. Plant Physiol 83: 272-277 [ Links ]

    112. NIJVELDT RJ, VAN NOOD E, VAN HOORN EC, BOELENS PG, VAN NORREN K, VAN LEEUWEN PAM (2001) Flavonoids: a review of probable mechanisms of action and potential applications. Am J Clin Nutr 74: 418-425 [ Links ]

    113. BRAND-WILLIAMS W, CUVELIER ME, BERSET C (1995) Use of free radical method to evaluate antioxidant activity. Lebensm Wiss Technol 28: 25-30 [ Links ]

    114. HALVORSEN BL, HOLTE K, MYHRSTAD MC, BARIKMO I, HVATTUM E, REMBERG SF, WOLD AB, HAFFNER K, BAUGEROD H, ANDERSEN LF, MOSKAUG O, JACOBS DR Jr, BLOMHOFF R (2002) A systematic screening of total antioxidants in dietary plants. J Nutr 132: 461-471
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