Revista clínica de periodoncia, implantología y rehabilitación oral
versión ISSN 0719-0107
MELLA, S et al. Association between chronic periodontitis, interleukin-6 (IL-6) and body mass index (BMI) in pregnant women. Rev. Clin. Periodoncia Implantol. Rehabil. Oral [online]. 2011, vol.4, n.3, pp. 97-101. ISSN 0719-0107. doi: 10.4067/S0719-01072011000300002.
Objective: To determine if maternal periodontal clinical status, body mass index (BMI) and its variation during pregnancy are associated with increased levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-) and C-reactive protein (CRP) in plasma. Material and Methods: This clinical study included a total of 56 pregnant women between 18 and 38 years old (mean 27.9 ± 7.04 years), referred from perinatal medicine unit at health care center Universidad de los Andes. All pregnant patients consented to voluntarily participate in the study. In each trimester of pregnancy, they underwent a complete periodontal examination, involving the determination of clinical attachment levels, probing depth, bleeding and hygiene index at six sites of each tooth, excluding third molars. Additionally, in each clinical check, peripheral blood samples were taken for determination of pro-inflammatory mediators with ELISA immunoassay. Periodontal diagnosis and inflammatory mediators were the variables analyzed in relation to changes in BMI during pregnancy. Results: Pregnant women with chronic periodontitis had an increase and more variation of BMI (p=0.039) and higher levels of IL-6 (p=0.026) in comparison with pregnant women with gingivitis. Conclusions: In this series of pregnant patients the clinical diagnosis of periodontitis, with an increase in BMI are associated with increased plasma levels of IL-6 and CRP.
Palabras clave : Gingivitis; periodontitis; body mass index; interleukin-6; tumor necrosis factor alpha; C reactive protein.