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Revista chilena de cardiología
versión On-line ISSN 0718-8560
SAAVEDRA, Nicolás et al. Single nucleotide polymorphism rs3091244 of CRP gene is associated with higher levels of hs-CRP in Chilean subjects. Rev Chil Cardiol [online]. 2011, vol.30, n.1, pp.22-27. ISSN 0718-8560. http://dx.doi.org/10.4067/S0718-85602011000100003.
Background: Several genes and their polymorphisms have been associated with atherosclerotic plaque formation and subsequent development of cardiovascular disease. One of them is the C-reactive protein (CRP) encoding gene, CRP being a recognized important pro-inflammatory and inflammatory marker. Biallelics and triallelics single nucleotide polymorphisms (SNPs) in the promoter region of this gene have been identified. The rs3040244 C>T>A is known as the variant most strongly associated with high hs-CRP levels. However, the results between populations are contradictory. Thus, the purpose of this study was to investigate the possible association between the rs3091244 polymorphism and serum levels of hs-CRP in Southern Chilean individuals. Methods: We determined the serum hs-CRP in 157 unrelated adult subjects. The rs3091244 polymorphism was detected by PCR-RFLP. Results: The genotype distribution for the rs3091244 polymorphism of the CRP gene was as follows: CC 11.5%, CT 45.2%, TT 31.2%, CA 5.0% and TA 7.0%. Individuals carrying the TT and TA genotypes showed higher serum hs-CRP when compared to the reference CC genotype (p = 0.030 and p = 0.002, respectively). Conclusion: Our data shows that the rs3091244 SNP of the CRP gene contributes to increase the hs-CRP levels, which may imply an increased cardiovascular risk.
Palabras clave : hs-CRP; CRP gene; Risk factors.