Revista chilena de cardiología
versión On-line ISSN 0718-8560
SALAZAR, Luis A et al. The presence of T allele for rs2781666 G>T common variant of arginase 1 gene constitutes a protector factor against coronary artery disease in southern Chilean subjects. Rev Chil Cardiol [online]. 2010, vol.29, n.3, pp. 316-321. ISSN 0718-8560. http://dx.doi.org/10.4067/S0718-85602010000300005.
Background: Recent data support a role for arginase 1 (ARG1) in the initiation, development, and compli-cations of coronary artery disease. Thus, in the present study we investigated the possible association between the rs2781666 G>T variant of ARG1 and the presence of CAD confirmed by angiography in Chilean subjects. Methods: A total of 124 unrelated patients with diagnosis of CAD confirmed by angiography (stenosis > 70%) and 123 healthy controls (30 - 74 years oíd) were in-cluded in this study. The rs2781666 G>T variant of the ARG1 gene was evaluated by PCR-RFLR Results: The frequency of TT homozygous genotype in CAD patients was lower when compared to control group (6.5% vs. 8.0%, p=0.032). Similarly, the T alíele frequency was different between CAD and control groups (0.230 vs. 0.325, p=0.031). The OR for CAD related to T alíele was 0.64 (95%CI. = 0.43-0.94), con-firming the association founded. Conclusión: These findings suggest that the T alíele for rs2781666 polymorphism of the ARG1 gene constitutes an inherited protective factor against CAD in Southern Chilean subjects.
Palabras clave : Coronary artery disease; Gene polymorphism; ARG1.