SciELO - Scientific Electronic Library Online

 
vol.29 número2Evaluación a largo plazo del impacto funcional y estructural de la arteria radial post acceso en intervencionismo coronarioAsociación de niveles de lípidos y haplogrupos Amerindios de DNA mitocondrial en individuos chilenos hipercolesterolémicos tratados con Atorvastatina índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Revista chilena de cardiología

versión On-line ISSN 0718-8560

Resumen

CUEVAS, Alejandro et al. SNP43 polymorphism of Calpain-10 gene in Southern Chilean subjects with coronary artery disease and controls. Rev Chil Cardiol [online]. 2010, vol.29, n.2, pp. 201-206. ISSN 0718-8560.  http://dx.doi.org/10.4067/S0718-85602010000200005.

Background: Diabetes mellitus type 2 (DMT2) is a well know cardiovascular risk factor and has been related to subclinic atherosclerosis, which might be explained by the presence of a common genetic basis in both diseases. Several polymorphisms of the cal-pain-10 gene (CAPNIO) have been associated with insulin resistance and DMT; nevertheless, there is insufficient evidence about their relation with corogene in Southern Chilean subjects iseasea ndc ontrols nary artery disease (CAD). Thus, in the present study we investigated the possible association between the SNP-43 variant of CAPNIO and the presence of CAD in Chilean subjects. Methods: A total of 218 unrelated patients with diagnosis of CAD confirmed by angiography (33-74 years old) and 194 healthy controls (30 - 68 years old) were included in this study. The SNP43 variant of the CAPNIO gene was evaluated by PCR-RFLP. Results: The genotype distribution for SNP43 variant of CAPNIO gene in CAD patients (GG: 51.4 %; GA: 42.7 %; AA: 5.9 %) and controls (GG: 59.6%; GA: 35.1%; AA: 5.2%) was similar (P=0.228). Similarly, the allelic frequency was no different (P = 0.200). The OR for CAD related to AA homozygous genotype was 1.17 (95%C.I. = 0.50 - 2.72), confirming the absence of association. Conclusion: These findings suggest that the SNP43 polymorphism of the CAPNIO gene is not associated to CAD in the studied individuals.

Palabras clave : Coronary artery disease; Gene polymorphism; CAPNIO.

        · resumen en Español     · texto en Español     · pdf en Español