Revista chilena de cardiología
versión On-line ISSN 0718-8560
CAAMANO L, José et al. TP53 codon 72 polymorphism is associated with coronary artery disease in Chilean subjects. Rev Chil Cardiol [online]. 2009, vol.28, n.2, pp.151-157. ISSN 0718-8560. http://dx.doi.org/10.4067/S0718-85602009000200002.
Background: Different genes have been implicated in the aetiology of coronary artery disease, among these, the TP53 gene. Recently, the codon 72 polymorphism (Pro72Arg, rs1042522) of TP53 gene was indicated as a risk factor for coronary artery disease (CAD). However, other authors do not confirm this observation. Thus, in the present study we investigated the possible association between this genetic variant and the presence of CAD in Chilean subjects. Methods: 209 unrelated patients with diagnosis of CAD confirmed by angiography (33-74 years old) and 216 healthy controls (30 - 68 years old) were included in this study. The Pro72Arg polymorphism of the TP53 gene was evaluated by PCR-RFLP. Results: The genotype distribution for Pro72Arg variant of TP53 gene in CAD patients (PP: 6.2%, PR: 29.2%, RR: 64.6%) and controls (PP: 8.3%, PR: 43.5%, RR: 48.1%) was significantly different (P=0.003). Similarly, the allelic frequency was also different (P = 0.003). The OR for CAD related to 72Arg alíele was 2.0 (95%C.I. = 1.33- 2.90). Conclusion: These findings suggest that the Pro72Arg polymorphism of the TP53 gene is associated with CAD in study Chilean individuals.
Palabras clave : cardiovascular risk factors; Genetic polimorfism; TP53.