Revista de otorrinolaringología y cirugía de cabeza y cuello
versión On-line ISSN 0718-4816
MERCADO M, Víctor; BURGOS S, Rodolfo y MUNOZ V, Claudio. Drug-induced ototoxicity. Rev. Otorrinolaringol. Cir. Cabeza Cuello [online]. 2007, vol.67, n.2, pp. 167-177. ISSN 0718-4816. doi: 10.4067/S0718-48162007000200013.
Ototoxicity is defined as the transient or definitive perturbations of the auditory and/ or vestibular function, induced by drugs of therapeutic use. Despite a large body of literature devoted to this subject, there are still unanswered questions, due to the complex consequences of cochleovestibular damage. The present study aims to review recent theories that try to explain the mechanism of action of involved drugs, from the viewpoint of pharmacokinetics/pharmacodynamics, cell and molecular biology. Our purpose is that recent advances in this matter could lead to a better understanding and safer clinical practice related to drug-induced ototoxicity, summarizing the care and precautions that should be taken when administering a known ototoxic drug
Palabras clave : Ototoxicity; vestibular toxicity; cochlear toxicity; ototoxic drugs.