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Revista de otorrinolaringología y cirugía de cabeza y cuello
versión On-line ISSN 0718-4816
BRUNETTO M, Beatriz y ZELADA B, Ursula. Use of cidofovir in recurrent respiratory papillomatosis. Rev. Otorrinolaringol. Cir. Cabeza Cuello [online]. 2007, vol.67, n.2, pp.153-156. ISSN 0718-4816. http://dx.doi.org/10.4067/S0718-48162007000200010.
Recurrent respiratory papillomatosis (RRP) is a disease caused by infection with the human papillomavirus (HPV), and is characterized by the presence of epithelial tumors in the airway. It is most commonly spread by direct contact, and it usually affects the larynx, but it may involve any region of the airway. Its symptoms vary from dysphonia to complete obstruction of the airway, and it may even cause death. in some cases, papillomas can become malignant and transform into epidermoid carcinoma. Current treatments are only palliative, and consist of the papillomas surgical resection in order to maintain the airway unobstructed and to improve voice quality; but it has a high recurrency rate, and usually several surgical procedures are needed, resulting in a high-cost treatment. Recently, cidofovir, an acyclic nucleoside phosphonate, has been used for the intralesional treatment of laryngeal papillomatosis with promising results, including complete remission in a high percentage of cases, and decreased recurrence
Palabras clave : Cidofovir; papilomatosis; virus papiloma humano.