Revista chilena de cirugía
versión On-line ISSN 0718-4026
BUTTE B, JEAN MICHEL et al. Prognostic factors of patients with colorectal liver metastases. Rev Chil Cir [online]. 2007, vol.59, n.4, pp. 293-298. ISSN 0718-4026. http://dx.doi.org/10.4067/S0718-40262007000400009.
Introduction: Liver metastases (LM) are frequent cause of death in patients with colorectal cancer (CRCa). Our aim was to evaluate factors determining overall survival in colorectal cancer liver metastases. Material and Methods: Data from 122 patients with LM of CRCa evaluated between 1978 and 2002 were retrospectively analyzed. Data was obtained from pathologic reports, patient's records and from a specially designed database. We studied demographic data, primary tumors, its treatment and liver metastases characteristics. Prognostic factors, recurrence and 5-year survival specific curves, calculated according to Kaplan-Meier were obtained. Results: Among the 122 patients [71 (58.2%) were men; mean age: 65 ± 13 years old], 73 (59.8%) had synchronic LM with the primary tumor. In 46 (37.7%) cases there were bilateral tumors; and in 70 (57.4 %) patients there were 4 or more lesions. Only 34 (27.9%) cases had a solitary LM. In 65 (53.3%) patients the primary tumor surgical treatment was considered curative (RO). In 42 (64.6%) of these patients LM were surgically resected. Eighteen patients developed cancer recurrence after liver resection at a mean time of 18 month. The overall 5-year survival of all patients was 14.6 %. Patients with more than one nodule, metastatic bilateral LM and no curative resection had the worst prognosis (p<0.0001). The 5-year survival rate of patients who underwent a RO liver resection was 46.2%. Conclusions: One third of this series were treated by liver resection. The best survival was obtained with a RO (negative margins) liver resection
Palabras llave : Colorectal carcinoma; liver metastases; surgical resection.